Director Track — Pharmacology

South San Francisco, CA

 

Trucode Gene Repair is pioneering novel synthetic gene editing technologies to treat and cure patients with devastating monogeneic diseases. We seek a highly skilled, motivated, and creative scientist ready to excel in a fast-paced and collaborative environment. Candidates should have exceptional pharmacology, cell and molecular biology training and experience. The successful candidate will be part of a dynamic and rewarding work environment where the abilities to effectively communicate and function in a team environment will be essential for success.

Responsibilities:

  • Direct and manage the activities of the Pharmacology group.

  • Design and perform proof-of-mechanism as well as proof-of-concept gene editing studies.

  • Design and manage preclinical in vivo pharmacology studies including efficacy, pharmacokinetic and biomarker studies, as well as early ADME and toxicology studies.

  • Execution of in vitro, ex vivo, and in vivo cell biology, molecular biology, and biochemistry analyses to analyze gene editing of lead candidates; ability to assist the team in the laboratory as necessary to train staff and advance projects.

  • Excellent communication and presentation skills supporting rigorous analysis, interpretation and presentation of experimental data across the company.

  • Collaborate with colleagues to ensure timeline adherence and project alignment to meet group and company goals.

  • Support external and internal projects via team meetings, presentations, and reports with an ability to represent the company to external scientific collaborators, granting agencies, investors and board members.

Essential Qualifications:

  • A PhD degree, postdoctoral training and seven or more years of significant industrial experience. Leveling in the director track will be determined on abilities and accomplishments.

  • In vivo pharmacology experience.

  • Strong background in mammalian gene therapy, gene editing, DNA repair or related fields.

  • Demonstrated experience with a broad range of cell and molecular biology techniques including mammalian cell culture and cell-based assays (both primary cells and cell lines), standard molecular cloning and genomics techniques.

Preferred Qualifications:

  • Demonstrated expertise in the field of hematopoiesis and hematological diseases.

  • Prior pharmaceutical development experience from concept-to-IND filing.

  • Experience manipulating primary human hematopoietic cells.

  • Experience with gene-editing and DNA/RNA/protein delivery.

  • Knowledge in DNA repair mechanisms and pathways.

  • Broad conceptual expertise with genomics technologies and hands-on expertise with assays such as microarray analyses, digital PCR and QPCR, and next-gen sequencing.

Trucode is proud to be an equal opportunity employer. We do not discriminate on the basis of race, sex, color, religion, age, national origin, marital status, disability, veteran status, genetic information, sexual orientation, gender identity or any other reason prohibited by law in provision of employment opportunities and benefits.

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