Research Scientist — Gene Editing, Biology

South San Francisco, CA

 

Trucode Gene Repair is pioneering a novel synthetic gene editing technology to treat and cure patients with devastating rare diseases. We seek a highly skilled, motivated and creative scientist ready to function in a fast-paced and collaborative environment. Candidates should have exceptional cell and molecular biology training and gene-editing experience. The successful candidate will be part of a fast-paced, dynamic, and rewarding work environment, where the abilities to effectively communicate and function in a team environment will be essential for success.

Responsibilities:

  • Design and perform proof-of-mechanism as well as proof-of-concept gene editing studies.

  • Hands-on execution of in vitro, ex vivo, and in vivo assays to analyze gene editing of development candidates.

  • Perform cell biology, molecular biology, and biochemistry analyses.

  • Analyze, interpret, and present experimental data.

  • Collaborate with colleagues to ensure timeline adherence and project alignment to meet group and company goals.

  • Support external and internal projects via team meetings, presentations, and reports.

  • Attention to detail and ability to operate independently.

  • Excellent communication and record keeping   skills.

Essential Qualifications:

  • A PhD degree, or equivalent, with 3-5 years of post-doctoral training or industrial experience.

  • Strong background in mammalian gene therapy/editing, RNA biology, DNA repair or related fields.

  • Hands-on experience with a broad range of cell and molecular biology techniques.

  • Experienced with mammalian cell culture (primary cells and cell lines), transient transfections, standard molecular cloning techniques, and cell-based assays.

  • Ability to multitask and readily adapt to change.

Preferred Qualifications:

  • Familiarity with the field of hematopoiesis and hematological diseases.

  • Experience manipulating primary human hematopoietic cells.

  • Experience with gene-editing (CRISPR/Cas9, ZFNs, TALENs) and DNA/RNA/protein delivery.

  • Knowledge in DNA repair mechanisms and pathways.

  • Broad conceptual expertise with genomics technologies and hands-on expertise with assays including microarray analyses, digital PCR and QPCR, and next-gen sequencing.

  • Experience in FACS, Luminex multiplex assays, and IHC/ICC/IF.

Trucode is proud to be an equal opportunity employer. We do not discriminate on the basis of race, sex, color, religion, age, national origin, marital status, disability, veteran status, genetic information, sexual orientation, gender identity or any other reason prohibited by law in provision of employment opportunities and benefits.

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